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MIF demonstrates chemokine-like function and was discovered to be a ligand of the two CXCR2 and CXCR4. Binding of MIF to those receptors enhances monocyte recruitment and leukocyte chemotaxis (determine one). In human chondrosarcoma cells, this recruitment is mediated by Gαi proteins and PI3K in T mobile adhesion by way of upregulation in the tran